Thirty-nine cases of invasive cervical cancer with human papillomavirus(HPV) DNA sequences were analyzed to determine if HPV type 16 or 18 has clinical or prognostic significance. HPV type was determined by Southern blot hybridization. HPV 16 was
detected in 12 cases, and HPV 18 in 5 cases. Sixty percent of HPV 18 tumors were grade Ⅲ (3 of 5), whereas 8.3% (1 of 12) of HPV 16 tumors and 5.6% (1 of 18) of HPV 16/18 negative tumors were grade Ⅲ. Age, clinical stage, histologic cell type,
lesion
size, and lymph node metastasis in relation to HPV type were not statistically significant. The mean age of HPV 16 group was 50 years, compared to 47 years for the HPV 18 group. Of 30 squamous carcinomas, HPV 16 was detected in 12 cases(40.0%),
and
HPV
18 in 4 case (13.3%). Of 4 adenosquamous and adenocarcinomas, HPV 16 was detected in 0 cases(0.0%), and HPV 18 in 1 case(25.0%). Among stage IB-IIA cancer, lymph node metastasis was associated with 20% of HPV 16 cases(2 of 10) as compared with
25%
of
HPV 18 cases(1 of 4) and 7.7% of HPV 16/18 negative cases(1 of 13). It is suggested that HPV type 18 might be associated with worse prognostic factors of invasive cervical cancer than HPV type 16.
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